Men’s health is a complex topic, and some common trends and factors contribute to men sometimes neglecting their health. Reasons for this might be social expectations and stereotypes, fear of weakness and vulnerability, Work and lifestyle pressures, risk-taking behaviour, as well as the reluctance to discuss mental health issues. Most men are affected by the same diseases that can affect anyone—heart disease, stroke, diabetes, cancer, depression. Men’s health involves a variety of gender-specific issues, like testosterone production, sexual health, and unique issues such as prostate cancer and benign prostate enlargement. Thus, men can take control of their health by eating a healthy diet, making simple lifestyle adjustments, and visiting the doctor regularly. Heart disease and stroke Heart disease comes in many forms. All its forms can lead to serious, fatal complications if undetected. It is estimated that heart disease is the leading cause of death for U.S. men, responsible for one in every four male deaths. Between 70 percent and 89 percent of sudden cardiac events occur in men. Stroke targets more than three million men. High blood pressure is common in males under the age of forty-five. Stem cell therapy has been investigated as a potential treatment for congestive and heart failure patients. Mesenchymal Stem Cells (MSCs) can differentiate into various types of cells, including heart cells. Studies have shown that stem cells can improve heart function in patients with congestive heart failure. Stem cells have been shown to stimulate the growth of new blood vessels and heart muscle cells, and improve the function of existing cardiac cells, thereby improving cardiac function and blood flow and reducing inflammation in the heart. A few studies have shown good outcomes whereby injecting patients with allogeneic umbilical cord MSCs significantly reduces the rate of heart attacks or strokes in patients with chronic heart failure. Stroke is the fifth leading cause of death for U.S. men; it kills about the same number each year as prostate cancer and Alzheimer’s disease combined. Men have strokes at younger ages than women. After a stroke, the brain stem can suffer damage, and stem cells have the potential to help heal this damage. Research has shown that stem cell therapy can promote functional recovery in stroke patients by replacing damaged neurons and promoting the growth of new brain tissue. Cord blood is emerging as a serious competitor in cell therapy for stroke. The main reason is that MNC from cord blood triggers less graft-versus–host reaction than adult sources of MNC. If clinical trials of allogeneic cord blood therapy for stroke continue to meet their endpoints, this could be an exciting new application for donated cord blood.  In the United States, about 795,000 people suffer a stroke each year, and 140,000 are fatal1-3. If only 1% of these patients received cell therapy, that would be comparable to the total number of allogeneic stem cell transplants per year in the United States10. Ultimately, a successful cord blood therapy will find itself in competition against cell therapy products for stroke that are already near approval.  The possibility to utilize cord blood cells as an “off-the-shelf” product (actually out of the cryogenic freezer) with no HLA matching would make cord blood more competitive against other cell therapies that are based on MSC and operate as universal donor products (1-3). Skin Cancer This cancer joins heart disease as the top two leading causes of death for men of all races—and it is largely preventable with proper skin care and regular check-ups. Melanoma, the most serious skin cancer, affects the sexes differently. Men are more likely to die of melanoma than women. This is true at any age. White adolescent males and young adult men are about twice as likely to die of melanoma as white females of the same age. Recent experimental studies in melanoma cell lines confirmed that umbilical cord mesenchymal stem cells (UCMSCs) exert antitumor effects on melanoma by inhibiting proliferation, inducing apoptosis, and suppressing the metastatic potential of these melanoma cell lines (4). High blood pressure Several studies have shown that men younger than sixty-five consistently have higher levels of hypertension compared to women of the same age group. While common, it is not inevitable and can be prevented, delayed, and treated. If ignored, it can lead to heart and kidney failure, vision problems, and even blindness. Stress, lack of physical activity, and being overweight or obese increase the odds, as do genetics. Pulmonary arterial hypertension (PAH) is a progressive illness characterized by chronically elevated blood pressure in pulmonary circulation that can lead to right-sided heart enlargement and failure. In advanced stages, PAH is considered non-curable (5). Clinical researchers in Germany recently reported the first successful treatment of (PAH) using a human umbilical cord mesenchymal stem cell (HUCMSC)-derived therapy. Depression and suicide In 2019, 69% of total reported suicides were men.  The most common cause of suicide is untreated depression, as 90% of individuals who commit suicide are depressed. Men are less likely to seek treatment for depression. Stem cell therapies have emerged as a standard for the treatment of both subacute and chronic inflammatory processes and neurological disorders. Investigations have suggested the potential use of adult stem cell therapy to treat several neurological conditions, such as multiple sclerosis, autoimmune encephalomyelitis, Alzheimer’s disease, other dementia conditions, Parkinson’s disease, and epilepsy. Most studies emphasize the immunomodulatory nature of adult stem cells, with their therapeutic efficiency related to neurological diseases, particularly triggering anti-inflammatory states. Recently, various studies have focused on treating depression with MSCs from various sources and the results from different experimental studies strongly support the potential therapeutic use of stem cells in treating depression (6). Diabetes Untreated diabetes in men can lead to erectile dysfunction and other urological problems, nerve damage (neuropathy), dehydration, and damage to the eyes, kidneys, and hearing. Men, after putting on weight, are more at risk for diabetes than women. Additionally, men typically store fat differently than women, which increases their risk. In a recent meta-analysis, clear evidence was provided for the superior efficacy